Christian Religious Education (CRE) is an important subject that helps to nourish students’ moral and spiritual development.Religious Education plays a greater role as a component of our education system. The Constitution of Kenya, various Education commissions that have been formed as discussed below emphasizes the need for Religious Education in the Curriculum at all levels of learning. This shows how important Religious Education is in the holistic development of learners and the society at large. However, the continued increase in enrolment in secondary schools has put pressure on the limited teaching and learning resources which is affecting the performance in CRE. Therefore, the purpose of this research is to Explore the Factors Affecting Teaching and Learning of CRE among secondary schools in Mwingi West Sub-County, Kitui county. The study is guided by the objectives on how teaching and learning resources, teaching methodology, learners’ perception and future career aspirations affect teaching and learning of CRE.The study participants included 288 students and 12 CRE teachers selected from 12 schools in mwingi west sub-county, kituiCounty. The researcher used questionnaires in data collection. Quantitative data was analyzed using the statistical packages for social sciences (SPSS). From the findings it shows that the perception of the students towards CRE was positive. They see CRE as an interesting subject and the parents play a major role on bringing their children on a Christian way.Finally, the students need more guidance on careers in their schools.From the findings the researcher made the following recommendations;Parents should bring up their children by teaching them Christian values, career guiders and counsellors should be invited in school to guide learners on careers related to CRE and teachers should develop different methodologies in teaching CRE to make it more interesting.